OUR NEWS


15/01/2023 News

Laigo co-founder Madelon Maurice receives additional Health Holland funding to study E3 ligases for targeted degradation of membrane proteins in cancer in partnership with Laigo Bio B.V.


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26/10/2022 Publication

RNF43 mutations facilitate mucinous colorectal cancer metastasis via formation of a tumour-intrinsic niche BioRxiv preprint 2022

Bugter JM, El Bouazzaoui L, Küçükköse E, Hong Y, Sprangers J, Jordens I, Fenderico N, Montiel Gonzalez D, Van Boxtel R, Suijkerbuijk SJE, Tejpar S, Snippert HJG, Kranenburg O, Maurice MM.


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28/07/2022 News

Laigo co-founder Madelon Maurice receives KWF and Health Holland funding to further study the innovative SureTAC technology, designed in collaboration with ArgoBio and Oncode, to degrade cancer-specific proteins

Prof. Madelon Maurice's group at UMC Utrecht has been awarded 1.2 million for its research into the effect of a new technology they have developed for eliminating cancer proteins. The project is funded by KWF, which stimulates public-private partnerships with government money through the top sector Life Sciences & Health (under the name Health-Holland).  Targeted...


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08/02/2022 News

Oncode Institute and ArgoBio launch Laigo Bio, a targeted protein degradation biotech with programs in oncology and neurological disorders

A collaboration for the creation of a company specialized in the development of a new biological approach for the treatment of cancer and neurological disorders.   Argobio and the Oncode Institute will support the company's development to Series A financing. Utrecht (Netherlands), and Paris (France), February 08th 2022 - ArgoBio and Oncode Institute have...


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26/10/2020 Publication

RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer - The EMBO Journal (2020)

Spit M., Fenderico N., Jordens I., Radaszkiewicz T., Lindeboom R.G., Bugter J.M., Cristobal A., Ootes L., van Osch M., Janssen E., Boonekamp K.E., Hanakova K., Potesil D., Zdrahal Z., Boj S.F., Medema J.P., Bryja V., Koo B., Vermeulen M., & Maurice M.M.  


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26/10/2012 Publication

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors - Nature (2012). PMID: 22895187

Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.


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